Early Detection of Chronic Thromboembolic Pulmonary Hypertension in Patients After Acute Pulmonary Embolism
The project is a national, prospective, multicenter, observational pilot project of screening CTEPH in pacients after APE in the Czech Republic. The main goal of the project is to methodically prepare, implement and evaluate a pilot project that will verify the suitability of the proposed procedure of early detection of Chronic tromboembolic pulmonary hypertesion in such a way as to ensure the maximum positive impact on the health of the population and high cost-effectiveness of the whole process.
• Age over 18 years
• Signed consent to participate in the project and GDPR
• Patients with an episode of acute pulmonary embolism in the last 3-12 months, with ongoing anticoagulation therapy:
‣ Patients with new-onset and ongoing or progressive dyspnea (min. NYHA II) after a pulmonary embolism episode or worsening of dyspnea after a pulmonary embolism episode compared to the status before the episode (at least 1 HYHA grade) or
⁃ Asymptomatic patients after a pulmonary embolism episode and at least one of the following risk factors:
• ECHO evidence of severe PH at diagnosis of PE (PASP \>60 mmHg)
• Antiphospholipid syndrome with triple positivity (presence of lupus anticoagulans + anti-beta-2-glycoprotein I (B2GPI) antibodies + anticardiolipin)
• Infected permanent venous inlets and cardiac pacing/defibrillation intravascular systems
• Presence of ventriculoatrial shunt for treatment of hydrocephalus
• Nonspecific intestinal inflammation (ulcerative colitis, Crohn's disease)
• History of splenectomy
• Myeloproliferative disorders
• Chronic osteomyelitis